Analysis tools for clinical trials

Randomization with fixed ratio (c:e)

Response rate for control (must be between 0&1) *
Response rate for experiment (must be between 0&1) *
Upper bound constraint for standard error for control arm *
Upper bound constraint for standard error for experiment arm *
Upper bound constraint for standard error for difference between response rates *
Design with fixed ratio for control arm (c) *
Design with fixed ratio for experiment arm (e) *

Results

Minimum sample size with 1:1 allocation design for control arm:



Minimum sample size with 1:1 allocation design for experiment arm:



Minimum sample size with given c:e allocation design for control arm:



Minimum sample size with given c:e allocation design for experiment arm:


Description

Computes the required sample size using the optimal designs with multiple constraints proposed in Mayo et al.(2010). This optimal method is designed for two-arm, randomized phase II clinical trials, and the required sample size can be optimized either using fixed or flexible randomization allocation ratios.

For further explanation please refer to this link


Department of Biostatistics, University of Kansas Medical Center